Sarah Gonzalez

Psychology PhD candidate
Behavioral Neuroscience Major

Sarah is a Psychology PhD candidate at University of California Los Angeles. As a Behavioral Neuroscience major, she studies the interaction between brain and behavior. Her current work in the lab of Dr. Michael Fanselow focuses on the behavioral and biological factors that promote susceptibility versus resilience to the effects of stress. Sarah received her B.S. from Brown University in 2012 and M.A. from UCLA in 2015, and is planning to graduate in early  2021.

professional interests

INTERESTS
  • Learning and memory
  • Fear, stress and anxiety
  • Neuroscience
  • Rodent models of psychiatric conditions
  • Science writing and communication
skills
  • Development and implementation of behavioral tests
  • Stereotaxic surgery, including cannulations and intracerebral injections
  • Breeding colony management
  • Data analysis and statistics
  • Research publication and presentation
  • Grant writing
  • Teaching and mentorship
SOFTWARE PROFICIENCY
  • SPSS
  • R
  • Microsoft Office
  • GraphPad Prism
  • EndNote
  • Noldus Ethovision
  • Med Associates VideoFreeze

PUBLICATIONS

The Cognitive Abilities of Crows

Psychology in Action, 2021

Link to article

A basomedial amygdala to intercalated cells microcircuit expressing PACAP and its receptor PAC1 regulates contextual fear

Journal of Neuroscience, 2021

AK Rajbhandari, JC Octeau, S Gonzalez, ZT Pennington, F Mohamed, J Trott, J … & MS Fanselow

Link to article

Learning Under Pressure: How Stress Alters Memory

Psychology in Action, 2021

Link to article

The role of the ventromedial prefrontal cortex and context in regulating fear learning and extinction

Psychology & Neuroscience, 2020

ST Gonzalez & MS Fanselow

Link to article

Sex Differences in Behavioral Sensitivities After Traumatic Brain Injury

Frontiers in Neurology, 2020

AN Hoffman, SL Watson, AS Makridis, AY Patel, ST Gonzalez, L Ferguson…& MS Fanselow

Link to article

Interactions between the hippocampus, prefrontal cortex, and amygdala support complex learning and memory

F1000Research, 2019

E Yavas, S Gonzalez & MS Fanselow

Link to article

Stress-enhanced fear learning, a robust rodent model of post-traumatic stress disorder

Journal of Visualized Experiments, 2018

AK Rajbhandari, ST Gonzalez & MS Fanselow

Link to article

Effects of embryonic exposure to polychlorinated biphenyls (PCBs) on anxiety-related behaviors in larval zebrafish

Neurotoxicology, 2016

ST Gonzalez, D Remick, R Creton & RM Colwill

Link to article

The Neuroscience of Altruism

Psychology in Action, 2015

Link to article

Pavlovian contextual and instrumental biconditional discrimination learning in mice

Behavioural Brain Research, 2013

ST Gonzalez, ES Welch & RM Colwill

Link to article

current projects

Susceptibility versus resilience to the effects of stress

(Left) Example enzyme-linked immunosorbent assay wellplate (Right) Modified version of the Open Field, an assay of anxiety in rodents

Post-traumatic stress disorder (PTSD) can develop after exposure to traumatic events and produces symptoms that severely impact quality of life including flashbacks, hyperarousal and avoidance of reminders of the traumatic experience. However, not everyone who experiences trauma develops PTSD, and the factors that promote susceptibility versus resilience to the effects of stress are poorly understood.

Rodent models that capture aspects of human disorders are powerful tools for unraveling the mechanisms of these conditions. In my dissertation work I am utilizing a rodent model of stress exposure that captures several aspects of PTSD to study the behavioral and biological factors that promote susceptibility versus resilience to the effects of stress.

How does stress affect the brain?

eGFP expression in slice of mouse brain tissue

One characteristic of post-traumatic stress disorder (PTSD) is an exaggerated response to mild stressors that are reminiscent of the original trauma, leading to inappropriate fear responses. However, the ways in which stress affects the brain to produce these changes are unclear.

In my dissertation work I am using sophisticated techniques including conditional gene deletion in transgenic mouse lines to study how biological changes in the brain following stress can impact fear learning and memory.

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